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Bristol Myers Squibb: Scientist I, Toxicology – Cell Therapy

Bristol Myers Squibb

This is a Full-time position in Seattle, WA posted December 27, 2020.

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.

In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change.

We bring a human touch to every treatment we pioneer.

Join us and make a difference.

Bristol Myers Squibb (BMS) is developing clinical-stage, novel cellular immunotherapies based on two distinct and complementary modalities Chimeric Antigen Receptor (CAR) and T Cell Receptor (TCR) technologies.

Our goal is to revolutionize medicine by re-engaging the body’s immune system to treat cancer.

The Drug Safety Evaluation Cell Therapy team at BMS is seeking an innovative research scientist with expertise in immuno-oncology and a broad laboratory skill set to develop platforms and technologies that will allow us to understand the safety of these exciting new classes of therapy.

The scientist will serve as an integral member of the team that supports all cell therapy programs at BMS and is responsible for establishing the preclinical safety strategy for new CAR and TCR targets.

The scientist will develop and refine in vitro and in vivo model systems to identify potential risks associated with CAR and TCR T cell products, reporting results to non-clinical development as well as global project teams.

Responsibilities: Design and conduct sophisticated experiments focused on prediction of on and off-target risks associated with CAR and TCR T cells including, but not limited to, development of the following: Cell and tissue-based in vitro models that facilitate understanding of T-cell activity against human cells and tissues Mouse and non-human primate CAR T in vivo models Proteomic-scale screening approaches for TCR T-cell off-target activity Develop deep expertise in engineered T-cell therapies with an emphasis on preclinical safety evaluation Formally communicate research to leadership, project teams, and collaborators Deliver on short-term project goals while driving innovation that shapes the future of safety evaluation for CAR and TCR T-cell modalities Represent Drug Safety Evaluation on cross-functional CAR and TCR T-cell global project teams Work closely with colleagues in research to identify and address toxicology implications of next-generation therapeutic strategies (gene editing, armoring, etc.) Participate in the evaluation of new CAR and TCR T-cell targets Prepare technical reports for inclusion in regulatory filings (IND, BLA) Identify, initiate, and support external academic collaborations Facilitate and monitor scientific studies conducted at external contract research organizations Represent BMS externally through publications and presentations at scientific conferences Technical skills : Proficiency in laboratory bench skills such as multi-color flow cytometry, cell sorting, ELISAs, Luminex, Mesoscale, western blots, IHC and qPCR or ddPCR Experience with genome editing methodologies and gene expression analysis Culture of primary and immortalized mammalian cells; familiarity with advanced cell culture platforms Analytical methods for functional characterization of T cells (activation, cytotoxicity, cytokine secretion, etc.) Fluorescence and/or confocal microscopy, live cell imaging and analysis (i.E.

Incucyte) Genetic engineering and cell line development Ability to work independently Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale Familiarity with in vitro and in vivo toxicology models, study design, and conduct is desirable Qualifications: Ph.D.

in immunology, bioengineering, biochemistry, molecular and cell biology, toxicology, or related discipline, with at least 2 years of relevant work experience preferred.

Master’s degree with at least 8 years of work experience or Bachelor’s degree with at least 10 years work experience.

Scientific expertise evidenced by strong publication record Excellent laboratory-based skills in cell and molecular biology Other Attributes Working knowledge of drug discovery and development process Track record of supervisory experience with research associates is desirable Exceptional written and oral communication skills Around the world, we are passionate about making an impact on the lives of patients with serious diseases.

Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment.

We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.